Tax-loss harvesting alternatives for VRTX

Among the 28 Biotechnology peers screened, AMGN (Amgen Inc.) has tracked VRTX most closely over the past year, with a return correlation of 0.49. The strongest fund stand-in is IBB (iShares Biotechnology ETF) at 0.66 over the past year. Correlations are computed from daily closing-price returns aligned by trading day.

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STOCKS

Single-name peers

Ticker	Name	Sub-industry	1Y	3Y	5Y	10Y
AMGN	Amgen Inc.	Biotechnology	0.49	0.38	0.38	0.44
BIIB	Biogen Inc.	Biotechnology	0.46	0.34	0.35	0.32
GILD	Gilead Sciences	Biotechnology	0.44	0.33	0.37	0.40
BMRN	BioMarin Pharmaceutical	Biotechnology	0.40	0.26	0.32	0.41
INCY	Incyte	Biotechnology	0.38	0.32	0.36	0.43
REGN	Regeneron Pharmaceuticals	Biotechnology	0.37	0.35	0.38	0.46
HALO	Halozyme	Biotechnology	0.35	0.21	0.24	0.31
VIR	Vir Biotechnology, Inc.	Biotechnology	0.32	0.24	0.23	0.12
EXEL	Exelixis	Biotechnology	0.31	0.20	0.23	0.33
KRYS	Krystal Biotech	Biotechnology	0.29	0.26	0.22	0.22
SRPT	Sarepta Therapeutics	Biotechnology	0.29	0.23	0.24	0.24
MRNA	Moderna Inc.	Biotechnology	0.28	0.21	0.20	0.18
NBIX	Neurocrine Biosciences	Biotechnology	0.27	0.21	0.26	0.35
CYTK	Cytokinetics	Biotechnology	0.27	0.17	0.19	0.23
ALNY	Alnylam Pharmaceuticals	Biotechnology	0.26	0.20	0.21	0.29
XNCR	Xencor Inc	Biotechnology	0.25	0.25	0.27	0.31
ROIV	Roivant Sciences	Biotechnology	0.24	0.22	0.22	—
VCEL	Vericel	Biotechnology	0.23	0.22	0.22	0.22
RCUS	Arcus Biosciences, Inc.	Biotechnology	0.22	0.22	0.22	0.24
ARWR	Arrowhead Pharmaceuticals	Biotechnology	0.22	0.25	0.28	0.26
UTHR	United Therapeutics	Biotechnology	0.21	0.19	0.25	0.30
TGTX	TG Therapeutics, Inc.	Biotechnology	0.21	0.19	0.21	0.24
RGEN	Repligen	Biotechnology	0.20	0.21	0.22	0.30
LGND	Ligand Pharmaceuticals, Inc.	Biotechnology	0.20	0.20	0.21	0.30
FTRE	Fortrea	Biotechnology	0.19	0.18	0.18	—
HRMY	Harmony Biosciences Holdings, Inc.	Biotechnology	0.19	0.13	0.18	—
ADMA	ADMA Biologics, Inc.	Biotechnology	0.19	0.20	0.22	0.15
PTGX	Protagonist Therapeutics, Inc.	Biotechnology	0.16	0.19	0.14	0.13

ETFS

Fund stand-ins

An ETF is generally not 'substantially identical' to a single stock, which is why funds are the standard wash-sale-aware replacement.

Ticker	Name	Focus	Match	1Y	3Y	5Y	10Y
IBB	iShares Biotechnology ETF	Biotechnology	INDUSTRY	0.66	0.56	0.55	0.62
IYH	iShares US Healthcare ETF	Health Care Sector	SECTOR	0.62	0.50	0.52	0.57
FHLC	Fidelity MSCI Health Care ETF	Health Care Sector	SECTOR	0.61	0.50	0.52	0.57
VHT	Vanguard Health Care ETF	Health Care Sector	SECTOR	0.61	0.50	0.52	0.57
XLV	Health Care Select Sector SPDR	Health Care Sector	SECTOR	0.60	0.49	0.52	0.56
PPH	VanEck Pharma ETF	Pharmaceuticals	INDUSTRY	0.54	0.44	0.47	0.51
IHE	iShares US Pharmaceuticals ETF	Pharmaceuticals	INDUSTRY	0.53	0.44	0.47	0.52
XBI	SPDR S&P Biotech ETF	Biotechnology (Equal Wt)	INDUSTRY	0.49	0.42	0.41	0.50
XPH	SPDR S&P Pharmaceuticals	Pharmaceuticals (Equal Wt)	INDUSTRY	0.39	0.36	0.40	0.46
ARKG	ARK Genomic Revolution ETF	Genomics (Active)	INDUSTRY	0.36	0.30	0.32	0.40
IHI	iShares Medical Devices ETF	Medical Devices	SUB-IND	0.32	0.27	0.34	0.44
IHF	iShares Health Care Providers	Health Care Providers	INDUSTRY	0.23	0.22	0.31	0.38

NEXT STEPS

Harvesting a loss in VRTX?

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Replacement research for VRTX's peers

AMGN BIIB GILD BMRN INCY REGN HALO VIR EXEL KRYS SRPT MRNA NBIX CYTK ALNY XNCR ROIV VCEL RCUS ARWR UTHR TGTX RGEN LGND FTRE HRMY ADMA PTGX

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Method: Pearson correlation of daily closing-price returns, Yahoo Finance data, series aligned by trading day, refreshed weekly. A cell is blank when overlapping history covers less than 60% of its window. Correlation is descriptive, not predictive. Wash-sale treatment depends on facts and circumstances — confirm with a tax professional. Not investment advice.