Tax-loss harvesting alternatives for ALNY

Among the 28 Biotechnology peers screened, AMGN (Amgen Inc.) has tracked ALNY most closely over the past year, with a return correlation of 0.32. The strongest fund stand-in is IYH (iShares US Healthcare ETF) at 0.39 over the past year. Correlations are computed from daily closing-price returns aligned by trading day.

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STOCKS

Single-name peers

Ticker	Name	Sub-industry	1Y	3Y	5Y	10Y
AMGN	Amgen Inc.	Biotechnology	0.32	0.29	0.24	0.27
SRPT	Sarepta Therapeutics	Biotechnology	0.27	0.21	0.23	0.24
VRTX	Vertex Pharmaceuticals	Biotechnology	0.26	0.20	0.21	0.29
EXEL	Exelixis	Biotechnology	0.25	0.18	0.21	0.31
GILD	Gilead Sciences	Biotechnology	0.23	0.20	0.22	0.23
INCY	Incyte	Biotechnology	0.21	0.22	0.22	0.30
HALO	Halozyme	Biotechnology	0.20	0.23	0.24	0.29
MRNA	Moderna Inc.	Biotechnology	0.19	0.13	0.18	0.18
NBIX	Neurocrine Biosciences	Biotechnology	0.19	0.26	0.28	0.36
BMRN	BioMarin Pharmaceutical	Biotechnology	0.18	0.23	0.27	0.33
FTRE	Fortrea	Biotechnology	0.17	0.15	0.14	—
RGEN	Repligen	Biotechnology	0.17	0.16	0.21	0.26
VIR	Vir Biotechnology, Inc.	Biotechnology	0.17	0.17	0.19	0.16
BIIB	Biogen Inc.	Biotechnology	0.15	0.22	0.24	0.23
ARWR	Arrowhead Pharmaceuticals	Biotechnology	0.14	0.24	0.33	0.28
HRMY	Harmony Biosciences Holdings, Inc.	Biotechnology	0.13	0.12	0.16	—
LGND	Ligand Pharmaceuticals, Inc.	Biotechnology	0.12	0.15	0.21	0.25
TGTX	TG Therapeutics, Inc.	Biotechnology	0.12	0.16	0.24	0.24
REGN	Regeneron Pharmaceuticals	Biotechnology	0.11	0.20	0.23	0.31
VCEL	Vericel	Biotechnology	0.11	0.13	0.23	0.20
CYTK	Cytokinetics	Biotechnology	0.11	0.16	0.20	0.22
ADMA	ADMA Biologics, Inc.	Biotechnology	0.11	0.17	0.21	0.16
XNCR	Xencor Inc	Biotechnology	0.10	0.16	0.21	0.27
UTHR	United Therapeutics	Biotechnology	0.09	0.17	0.16	0.23
RCUS	Arcus Biosciences, Inc.	Biotechnology	0.07	0.17	0.23	0.24
PTGX	Protagonist Therapeutics, Inc.	Biotechnology	0.06	0.11	0.15	0.13
ROIV	Roivant Sciences	Biotechnology	0.05	0.17	0.16	—
KRYS	Krystal Biotech	Biotechnology	0.04	0.16	0.14	0.17

ETFS

Fund stand-ins

An ETF is generally not 'substantially identical' to a single stock, which is why funds are the standard wash-sale-aware replacement.

Ticker	Name	Focus	Match	1Y	3Y	5Y	10Y
IYH	iShares US Healthcare ETF	Health Care Sector	SECTOR	0.39	0.37	0.36	0.37
VHT	Vanguard Health Care ETF	Health Care Sector	SECTOR	0.39	0.38	0.37	0.38
FHLC	Fidelity MSCI Health Care ETF	Health Care Sector	SECTOR	0.39	0.37	0.37	0.38
IBB	iShares Biotechnology ETF	Biotechnology	INDUSTRY	0.39	0.44	0.48	0.51
XLV	Health Care Select Sector SPDR	Health Care Sector	SECTOR	0.37	0.34	0.32	0.33
IHI	iShares Medical Devices ETF	Medical Devices	SUB-IND	0.31	0.28	0.31	0.31
PPH	VanEck Pharma ETF	Pharmaceuticals	INDUSTRY	0.30	0.29	0.26	0.32
XBI	SPDR S&P Biotech ETF	Biotechnology (Equal Wt)	INDUSTRY	0.29	0.38	0.44	0.50
IHE	iShares US Pharmaceuticals ETF	Pharmaceuticals	INDUSTRY	0.29	0.32	0.31	0.37
XPH	SPDR S&P Pharmaceuticals	Pharmaceuticals (Equal Wt)	INDUSTRY	0.19	0.29	0.35	0.39
ARKG	ARK Genomic Revolution ETF	Genomics (Active)	INDUSTRY	0.18	0.26	0.36	0.40
IHF	iShares Health Care Providers	Health Care Providers	INDUSTRY	0.18	0.17	0.23	0.25

NEXT STEPS

Harvesting a loss in ALNY?

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Replacement research for ALNY's peers

AMGN SRPT VRTX EXEL GILD INCY HALO MRNA NBIX BMRN FTRE RGEN VIR BIIB ARWR HRMY LGND TGTX REGN VCEL CYTK ADMA XNCR UTHR RCUS PTGX ROIV KRYS

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Method: Pearson correlation of daily closing-price returns, Yahoo Finance data, series aligned by trading day, refreshed weekly. A cell is blank when overlapping history covers less than 60% of its window. Correlation is descriptive, not predictive. Wash-sale treatment depends on facts and circumstances — confirm with a tax professional. Not investment advice.