Tax-loss harvesting alternatives for PTGX

Among the 28 Biotechnology peers screened, XNCR (Xencor Inc) has tracked PTGX most closely over the past year, with a return correlation of 0.30. The strongest fund stand-in is XBI (SPDR S&P Biotech ETF) at 0.44 over the past year. Correlations are computed from daily closing-price returns aligned by trading day.

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STOCKS

Single-name peers

Ticker	Name	Sub-industry	1Y	3Y	5Y	10Y
XNCR	Xencor Inc	Biotechnology	0.30	0.29	0.24	0.21
ROIV	Roivant Sciences	Biotechnology	0.28	0.28	0.24	—
VIR	Vir Biotechnology, Inc.	Biotechnology	0.26	0.22	0.20	0.11
REGN	Regeneron Pharmaceuticals	Biotechnology	0.25	0.25	0.18	0.13
CYTK	Cytokinetics	Biotechnology	0.25	0.18	0.19	0.16
NBIX	Neurocrine Biosciences	Biotechnology	0.25	0.17	0.15	0.12
TGTX	TG Therapeutics, Inc.	Biotechnology	0.23	0.25	0.27	0.18
LGND	Ligand Pharmaceuticals, Inc.	Biotechnology	0.22	0.20	0.23	0.15
KRYS	Krystal Biotech	Biotechnology	0.21	0.27	0.18	0.16
HRMY	Harmony Biosciences Holdings, Inc.	Biotechnology	0.20	0.18	0.17	0.15
RCUS	Arcus Biosciences, Inc.	Biotechnology	0.20	0.28	0.26	0.15
ARWR	Arrowhead Pharmaceuticals	Biotechnology	0.19	0.20	0.24	0.14
VRTX	Vertex Pharmaceuticals	Biotechnology	0.19	0.19	0.15	0.13
EXEL	Exelixis	Biotechnology	0.19	0.18	0.18	0.16
SRPT	Sarepta Therapeutics	Biotechnology	0.17	0.14	0.11	0.11
INCY	Incyte	Biotechnology	0.17	0.18	0.15	0.11
UTHR	United Therapeutics	Biotechnology	0.15	0.09	0.07	0.11
GILD	Gilead Sciences	Biotechnology	0.15	0.16	0.14	0.11
BMRN	BioMarin Pharmaceutical	Biotechnology	0.14	0.16	0.18	0.14
AMGN	Amgen Inc.	Biotechnology	0.14	0.19	0.09	0.10
HALO	Halozyme	Biotechnology	0.12	0.18	0.16	0.16
BIIB	Biogen Inc.	Biotechnology	0.12	0.18	0.17	0.11
ADMA	ADMA Biologics, Inc.	Biotechnology	0.10	0.20	0.20	0.13
RGEN	Repligen	Biotechnology	0.07	0.07	0.13	0.12
VCEL	Vericel	Biotechnology	0.06	0.18	0.22	0.15
ALNY	Alnylam Pharmaceuticals	Biotechnology	0.05	0.10	0.15	0.13
MRNA	Moderna Inc.	Biotechnology	0.05	0.09	0.11	0.08
FTRE	Fortrea	Biotechnology	0.03	0.06	0.04	—

ETFS

Fund stand-ins

An ETF is generally not 'substantially identical' to a single stock, which is why funds are the standard wash-sale-aware replacement.

Ticker	Name	Focus	Match	1Y	3Y	5Y	10Y
XBI	SPDR S&P Biotech ETF	Biotechnology (Equal Wt)	INDUSTRY	0.44	0.43	0.41	0.30
IBB	iShares Biotechnology ETF	Biotechnology	INDUSTRY	0.38	0.37	0.34	0.26
XPH	SPDR S&P Pharmaceuticals	Pharmaceuticals (Equal Wt)	INDUSTRY	0.37	0.34	0.30	0.25
IHE	iShares US Pharmaceuticals ETF	Pharmaceuticals	INDUSTRY	0.31	0.28	0.21	0.21
FHLC	Fidelity MSCI Health Care ETF	Health Care Sector	SECTOR	0.24	0.27	0.23	0.21
VHT	Vanguard Health Care ETF	Health Care Sector	SECTOR	0.24	0.26	0.23	0.21
PPH	VanEck Pharma ETF	Pharmaceuticals	INDUSTRY	0.23	0.22	0.18	0.19
IYH	iShares US Healthcare ETF	Health Care Sector	SECTOR	0.21	0.24	0.21	0.19
XLV	Health Care Select Sector SPDR	Health Care Sector	SECTOR	0.20	0.23	0.19	0.18
ARKG	ARK Genomic Revolution ETF	Genomics (Active)	INDUSTRY	0.19	0.26	0.29	0.24
IHF	iShares Health Care Providers	Health Care Providers	INDUSTRY	0.07	0.12	0.14	0.17
IHI	iShares Medical Devices ETF	Medical Devices	SUB-IND	0.02	0.13	0.18	0.17

NEXT STEPS

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Replacement research for PTGX's peers

XNCR ROIV VIR REGN CYTK NBIX TGTX LGND KRYS HRMY RCUS ARWR VRTX EXEL SRPT INCY UTHR GILD BMRN AMGN HALO BIIB ADMA RGEN VCEL ALNY MRNA FTRE

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Method: Pearson correlation of daily closing-price returns, Yahoo Finance data, series aligned by trading day, refreshed weekly. A cell is blank when overlapping history covers less than 60% of its window. Correlation is descriptive, not predictive. Wash-sale treatment depends on facts and circumstances — confirm with a tax professional. Not investment advice.